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Meanwhile, proteases and ROS released by infiltrating inflammatory cells can directly disrupt the mitochondrial membrane integrity of renal tubular epithelial cells, inducing mitochondrial apoptosis

A meta-analysis of global birth prevalence of spina bifida showed that when a national, mandatory program to fortify the diet with folate was compared to countries without such a fortification program, there was a 30% reduction in live births with spina bifida