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A recent meta-analysis by Apperloo and colleagues provides evidence that addition of an SGLT2 inhibitor to a GLP-1 receptor agonist effectively reduces cardiovascular events and progression of chronic kidney disease in high-risk type 2 diabetes patients

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Because DSIP has not been thoroughly studied in humans, people who are pregnant or breastfeeding, have significant medical conditions, or take multiple medications should avoid using it unless advised by a qualified healthcare professional

Retatrutide activated all three receptors with an unbalanced activity profileshowing the highest relative potency at GIPR