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Novo Nordisk and Gilead have planned a further Phase 2b study beginning in the second half of 2021 to analyze the effect of Semaglutide alone and in combination with Cilofexor and/or Firsocostat on liver fibrosis improvement and NASH resolution in 440 NASH patients with compensated cirrhosis

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And a small percentage might even experience weight gain, although this is far less common than with many other antidepressants

The weight loss comes primarily from reduced caloric intake driven by the medications appetite-suppressing effects