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Eligible patients were evaluated by a PCP for medication optimization at routine scheduled appointments (Fig
Net margins contract to around 15% due to lower volumes and pricing pressure, causing EPS to flatten or fall to $1.6 or less
Timing Considerations Timing considerations favor consistency over specific time selection
Novo Nordisk (Present Leader - Semaglutide Portfolio) CagriSema Mechanism: GLP-1 + Amylin agonist Stage: Phase 3 Expected filing: 2026 Weight loss: ~22-23% in trials Amycretin Mechanism: GLP-1 + Amylin Route: injectable + oral research Stage: Phase 2 Next-gen Oral GLP-1 programs Partnership with biotech firms to develop new oral obesity drugs 2
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