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While short-term LC supplementation has demonstrated positive effects, including increased endurance, improved hepatic fat metabolism, and myocardial stability, evidence indicates that the prolonged supplementation may pose risks, particularly for individuals with pre-existing cardiovascular or renal conditions

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Examples Glyburide [glybenclamide] (Glynase) Dosage Micronized Initial: 0.753 mg once daily with the first main meal Maximum: 12 mg daily Conventional: Initial: 1.255 mg once daily with the first main meal Maximum: 20 mg daily Glipizide (Glucotrol, Glucotrol XL) Dosage Immediate release Initial: 2.55 mg daily 30 minutes before first meal