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Compared with EtOH-fed WT mice, KO mice were less susceptible to EtOH-induced deleterious effects, including body weight loss (reflected by less body weight gain), liver weight gain and hepatocyte damage (reflected by plasma ALT activity) (Table 1)

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Gclc w/f or Gclc w/w mice (Gclc WT) and Gclc f/f mice (hereafter referred to as Gclc L-KO) were monitored following tail-vein injection with AAV-TBG-Cre (Fig