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Although current evidence supports the potential of TCMPs as therapeutic candidates for RA, the conclusions should be interpreted with caution due to generally low study quality and high heterogeneity
For acidic peptides (net negative charge, rich in Asp/Glu), reconstituting in a slightly basic solution (e.g., 0.1 M ammonium bicarbonate or a few drops of dilute NaOH) can improve solubility by deprotonating acidic groups
Cell 140 , 4961 (2010)
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