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The FDA does require a boxed warning for GLP-1 receptor agonists (Wegovy, Saxenda) and the dual GIP/GLP-1 receptor agonist tirzepatide (Zepbound) regarding thyroid C-cell tumors, based on rodent studies, though human relevance remains uncertain
According to the Centers for Disease Control and Prevention, a body mass index of 30 or higher indicates obesity and a body mass index of 25 to 29.9 is considered overweight
The liver has no GLP-1 or GIP receptors but is rich in glucagon receptors, which makes retatrutide an attractive option in the nephrology community
