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Here is the honest state of the data: Obesity (Phase 2, randomized controlled trial): the landmark New England Journal of Medicine Phase 2 trial in obesity established both the once-weekly dosing and the escalation approach, and reported the largest average weight reductions seen for a once-weekly agent with the caveat that the reduction had not fully plateaued at 48 weeks
Myth: GLP-1 medications will ruin your thyroid function
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Dosing Phases & Cycling 5-Amino-1MQ is a metabolic-enzyme modulator, so the documented research pattern treats it as a run-in, steady-state, then off compound rather than something you pulse and stop
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