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In people with variants (SNPs) that limit GHC1, their BH4 levels werent able to rise enough to respond to inflammation.[ref] ( GCH1 gene in the genotype report section ) Interestingly, the researchers in the above study used vaccination as an acute model of systemic inflammation to determine how the GCH1 gene variant affected the increase (or lack thereof) of BH4 levels in the study participants
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