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5 Krieger, C

For example, if you always want to draw 50 units (0.50 mL) per dose for consistency: At 2.5 mg dose: Reconstitute for 5 mg/mL (2.5 divided by 5 = 0.50 mL) At 5 mg dose: Reconstitute for 10 mg/mL (5 divided by 10 = 0.50 mL) At 7.5 mg dose: Reconstitute for 15 mg/mL (7.5 divided by 15 = 0.50 mL) This "consistent draw" approach reduces the chance of dosing errors when transitioning between dose levels because you always draw the same volume

Oxombre B, Lee-Chang C, Duhamel A, Toussaint M, Giroux M, Donnier-Marchal M, et al

Mutations of the interfacial residues in DET1 to glycine or alanine, including R488A/H485G, R488A/H485G/R306G/S312G or R488A/H485G/E380A/T382A reduced the interaction between DET1 and COP1