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Strategies to Mitigate GI Side Effects Gradual dose escalation: Slowly increasing the dose over several weeks reduces the likelihood of severe nausea and vomiting

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The 12-week rotation protocol Week 1: Right abdomen, upper quadrant (above navel, right side) Week 2: Left abdomen, upper quadrant (above navel, left side) Week 3: Right anterior thigh, upper portion Week 4: Right abdomen, lower quadrant (below navel, right side) Week 5: Left abdomen, lower quadrant (below navel, left side) Week 6: Left anterior thigh, upper portion Week 7: Right abdomen, lateral (right side, toward hip) Week 8: Left abdomen, lateral (left side, toward hip) Week 9: Right anterior thigh, lower portion Week 10: Right upper arm (if partner available) or right abdomen central Week 11: Left anterior thigh, lower portion Week 12: Left upper arm (if partner available) or left abdomen central After week 12, restart the cycle

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