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Imaging studies revealed diminished activation in brain regions such as the insula, putamen, and orbitofrontal cortex when exposed to high-calorie food cues, suggesting that GLP1-S reshapes both physiological hunger responses and the motivational aspects of eating

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In contrast, although Popular Pathways have gained increasing attention in recent years, less comprehensive research has been conducted, resulting in a limited number of genes on which natural products can act and consequently fewer identified natural products