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Unlike older weight loss medicines that often act on the brain or must be taken daily, retatrutide is not psychoactive and strikes directly at metabolic pathways
Recently, several multi-targeting agonists of GIPR, GLP-1R, or GCGR for treating T2DM and obesity have been in clinical trials
This suggested that central GLP-1 had a physiological role in regulating food intake in rats and GLP-1R may be necessary for the anorectic effect
JAMA Netw Open 2024;7:e2350050.ArticlePubMedPMC 111
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