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Studies have demonstrated that lentivirus-mediated overexpression of FoxO3a can induce the expression of ACAN and COL2A1, and reverse IL-1-induced chondrocyte apoptosis and inflammatory responses ( Table 5 ) ( Gene therapy faces numerous challenges, particularly the immunogenicity induced by viral vectors and gene editing tools, which can easily trigger host immune responses
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In 2013, Phongmitr et al
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