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1 Like most complex genomic regulatory systems, Nrf2 (nuclear factor erythroid 2-related factor 2) is sequestered in the cytoplasm until it is able to translocate into the nucleus, where it forms a heterodimer with MAF (another transcription factor) and binds to the promoter region of genes containing an antioxidant response element (ARE) sequence

Despite reports of positive outcomes from simultaneous agonism of both GLP-1R and Y2-R, this approach alone has not generated the same clinical benefits as obesity surgery 64,65,66

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Moreover, the optimal dose and formulation of melatonin for older adults require clarification sustained-release melatonin might better mimic the natural profile and sustain sleep through the night, for instance (Thanawala et al., 2024)