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The semaglutide component follows the same dose escalation schedule as standard compounded semaglutide: Weeks 1-4: 0.25 mg semaglutide (0.1 mL) Weeks 5-8: 0.5 mg semaglutide (0.2 mL) Weeks 9-12: 1.0 mg semaglutide (0.4 mL) Weeks 13-16: 1.7 mg semaglutide (0.68 mL) Week 17+: 2.4 mg semaglutide (0.96 mL) The niacinamide dose scales proportionally with the injection volume