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doi:10.6118/jmm.21010
These modifications include acylation of the peptide backbone with a spacer and a C-18 fatty di-acid chain to lysine at position 26, which mediates strong binding to albumin and potentially results in reduced renal clearance, and an amino-acid substitution in position 8, which results in reduced susceptibility to dipeptidyl peptidase-4 (DPP-4) degradation
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Patients may experience increased pain or discomfort at the injection site if the medication is delivered into muscle rather than subcutaneous tissue
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