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To increase aqueous solubility of the compounds to facilitate structural studies, the cycloheptyl substituent in TGR uncompetitive inhibitor 8 was replaced with a sugar moiety, resulting in compound 9 , a noncompetitive inhibitor and thus capable of binding the enzyme in absence of NADPH

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"Mulberry leaf extract improves glycaemic response and insulaemic response to sucrose in healthy subjects." PLOS ONE

Historically, berberine has been used for treating certain types of ailments, infections, and more