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There were two other dual agonists whose sequence has been reported so far, Tyr 1 has been used in MAR709 (designed by Finan et al in 2013, described by numerous other names: DA5-CH, DA-JC1, NNC0090-2746, RG7697, etc.) and His 1 has been used in CY-5 (Figure 3)

Serious adverse events were rare and not dose-dependent

For children some degree of both hypercholesterolemia and hypertriglyceridemia are reported, raising concerns about future cardiovascular disease (60, 8587)

GLP-1 agonist mechanism of action in cardiovascular tissues Once activated, GLP-1 receptors trigger multiple signaling pathways that collectively contribute to cardioprotection