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Local injection is typically placed in the subcutaneous tissue near the injured area, not directly into a tendon, ligament, nerve, blood vessel, or joint unless a specific procedural approach is being performed by a qualified clinician

More serious concerns include a possible increased risk of pancreatitis (inflammation of the pancreas) and, in animal studies, thyroid C-cell tumors

While this is not a side effect in the traditional sense, it's important to be aware that long-term use of high doses for skin-lightening purposes may have unintended consequences and may not be safe