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A study on whether and how the activation of GLP-1R affects proliferation and apoptosis of human pancreatic cancer cells has demonstrated that GLP-1RAs might activate cAMP in a GLP-1R-dependent manner, subsequently inhibiting the AKT and ERK1/2 signaling pathways, hence inhibiting the growth of transplanted tumors in vivo , as well as inducing apoptosis and inhibiting the proliferation of a human pancreatic cancer cell line in vitro ( 225)
Wegovy also contains semaglutide but is approved for weight loss rather than type 2 diabetes
doi: 10.3389/fimmu.2024.1407782 201 CamisaCSr.PapaveroV
7.2 Comparing with the novel metabolic target drugs As the FXR-activating function of GLP-1RAs, FXR agonists may have the same effect as GLP-1RAs (Errafii et al., 2022)
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