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Recent studies suggest that combining NAMPT inhibitors with other therapies could enhance their efficacy and reduce resistance in cancer treatment, as shown in various preclinical animal models 217,218
However, doses of 20-40 mg/kg should be limited to a maximum of 6 months
By the time most patients are in their late 30s or 40s, pineal calcification and reduced melatonin synthesis have already begun degrading sleep architecture, particularly the slow-wave deep sleep phases where cellular repair, growth hormone release, and memory consolidation occur
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