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UK approval through the MHRA typically follows FDA approval by 6 to 12 months

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In the context of exendin-4, the -phe1 substitution is known to reduce binding affinity, reduce GLP-1R endocytosis, accelerate GLP-1R recycling, enhance insulin release, and improve anti-hyperglycaemic efficacy, while exendin-asp3 shows opposing characteristics (Jones et al., 2018b)