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This intervention not only preserves the primordial follicle reserve but also enhances ovarian sensitivity to gonadotropins, as evidenced by improved ovarian responses in women with diminished ovarian reserve following CoQ10 pretreatment (Teppa-Garrn et al., 2025)

Compared to the recovered cases, there was a strong enrichment in upregulated terms for pathways related to T cell differentiation and activation (for example, PRDM1, TNF), TGF signaling (for example, SMAD3 , SNAI1 , SMURF1 ) and regulation of angiogenesis (for example, HES1 , DLL1 , HIF1A ), while there was downregulation in genes involved in platelet activation, signaling and aggregation (for example, PF4V1 , PF4 , TREML1 ) and hemostasis (for example, F13A1 , GP1BA , GP1BB ) (Fig