StatPearls [Internet], 2023 June Takaaki Sugihara, Masahiko Koda, Toshiaki Okamoto, Kenichi Miyoshi, Tomomitsu Matono, Kenji Oyama, Keiko Hosho, Jun-ichi Okano, Hajime Isomoto, Yoshikazu Murawaki
Because B12 is water-soluble, the body stores a reserve typically 1,000 to 2,000 mcg (12 mg) in the liver which is why deficiency can take years to **develop** even after dietary intake or absorption drops
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Injections can seem less convenient than oral supplements, but theyre particularly beneficial for people with severe deficiencies or malabsorption issues