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Clinical Evidence Several clinical trials and studies underscore the cardiovascular benefits of GLP-1 receptor agonists: SUSTAIN-6 Trial : This pivotal trial demonstrated a significant reduction in major adverse cardiovascular events (MACE) among patients treated with GLP-1 compared to placebo
Interestingly, heterozygous KEAP1 mutations frequently occur in lung cancers (Singh et al., 2006
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Insulin resistance, as well as the conditions of hyperinsulinemia, hyperglycemia, and elevated free fatty acids, play a substantial role in causing injury to cardiomyocytes, deteriorating their functionality, and leading to myocardial lipotoxicity in individuals with diabetes [88]
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