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A 2025 review by Mortazavi and Mohammadi Vadoud in BioImpacts flagged skin permeability as the main barrier to translating topical GHK-Cu data into clinical outcomes the compound does not reliably penetrate intact skin at concentrations used in topical products
Our team strongly recommends discarding it
Realistic Expectations for Combination Therapy While the data on combining GLP-1s and naltrexone is promising, it is important to have realistic expectations
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Driesen NR, McCarthy G, Bhagwagar Z, Bloch M, Calhoun V, D'Souza DC et al (2013)
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