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A typical approach might begin with Retatrutide alone for 4 to 8 weeks, add BPC-157 during dose escalation when GI symptoms peak, introduce TB-500 after reaching maintenance Retatrutide doses, and finally add GHK-Cu when significant weight loss begins affecting skin appearance

By this point, substantial new collagen has been deposited, elastin fibers have increased, and extracellular matrix remodeling has progressed meaningfully

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and BPC-157 supports local vascularity and inflammation control