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Further research is needed to determine whether eating foods rich in vitamin B12 or taking supplements can improve headaches

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[4] At the cellular level, free estradiol diffuses through cell membranes and binds to intracellular estrogen receptors and , which upon ligand activation dimerize and translocate to estrogen-response elements on nuclear DNA, modulating transcription of genes governing reproductive tract integrity, thermoregulation, bone metabolism, and vascular endothelial function

There is no binding partner established for any of them, no published saturable binding curve that has been independently reproduced, and no genetic model in which deleting a candidate target abolishes a reported effect