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There was also an improvement in the levels of low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, and triglycerides in participants who received retatrutide compared to placebo, which did not show improvement

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According to the NIDDK, these medications reduce appetite and slow gastric emptying, which increases fullness and decreases hunger the same mechanism that supports weight management goals but also means many users eat significantly less food than before

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