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These findings highlight the importance of TREM2 in promoting microglia polarization to the M2 anti-inflammatory phenotype and alleviating cognitive dysfunction ( 2.4 Metabolic and mitochondrial dysfunction in diabetes An animal experiment using db/db mice, a model of type 2 diabetes, demonstrated that disturbances in circulatory metabolism and brain energy metabolism, particularly mitochondrial dysfunction, may contribute to cognitive impairment

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10.1002/iub.1616 11 GioulekaS.TsakiridisI.ArsenakiE.KalogiannidisI.MamopoulosA.PapanikolaouE.et al (2023)