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While studies attempting to localize the pathology in FMS to peripheral tissues have failed in showing any abnormalities in muscle tissue, Staud and coworkers did show that enhanced central pain processing can occur via continued peripheral muscle afferent input, Their study demonstrated that muscle lidocaine injections increased local pain thresholds and decreased remote secondary heat hyperalgesia in fibromyalgia patients, emphasizing the important role of peripheral impulse input in maintaining central sensitization

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The observed benefits include improved skin laxity, firmness, reduced lines, and increased skin density and thickness [15]

Oral supplementation has shown effectiveness but may not match the efficacy of IM in certain scenarios