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Landmark findings from the STEP UP trials Tripling the standard dose of semaglutide a widely prescribed glucagon-like peptide-1 receptor agonist (GLP-1RA) resulted in markedly greater weight loss and cardiometabolic benefits, according to results from two large multicentre clinical trials led by UT Southwestern Medical Center

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Besides Cagrilintide, there are other insulin-based molecules in early clinical trial phases, including long-acting insulin agonists and a dual receptor agonist that binds both insulin and calcitonin activities