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For example, co-inhibition of ACC in hepatocytes and TLR4 in Kupffer cells markedly reduces both steatosis and fibrosis ( Simultaneous targeting of hepatocytes, Kupffer cells, hepatic stellate cells, and pancreatic -cells offers a synergistic approach to treat both MASH and T2DM by addressing steatosis, inflammation, fibrosis, and insulin resistance

Mechanical stress and impingement can generate reactive oxygen species (ROS), which are chemically reactive molecules containing oxygen

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